There are two architectural alternatives I'm looking at;
1. Home runs of speakerwire direct to speaker, or line level embedded amps, or
2. Ethernet or wireless to RPis which then drive the amps/speakers
#1 is the simplest, though doesn't cover use cases C and D below, at least with standard high impedance microphones. Low impedance mikes may, though are not inexpensive and require special interfacing.
#2 is far more capable, and allows far more home automation and security (e.g., attached webcam with video analytics on a central server)
A. Whole house audio: home runs from a central patch panel are acceptable
B. Play wake up sounds (surf, jungle, etc) in individual bedrooms
C. Whole house intercom (controls could vary, call could even be placed on a smartphone)